Characterization of a Discontinuous Epitope of the HIV Envelope Protein gp120 Recognized by a Human Monoclonal Antibody Using Chemical Modification and Mass Spectrometric Analysis

A subset of the neutralizing anti-HIV antibodies recognize epitopes on the envelope protein gp120 of the human immunodeficiency virus. These epitopes are exposed during conformational changes when gp120 binds to its primary receptor CD4. Based on chemical modification of lysine and arginine residues...

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Détails bibliographiques
Auteurs principaux: Hager-Braun, Christine, Hochleitner, Elisabeth O., Gorny, Miroslaw K., Zolla-Pazner, Susan, Bienstock, Rachelle J., Tomer, Kenneth B.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008351/
https://ncbi.nlm.nih.gov/pubmed/20434359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2010.03.031
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