Activation of a Silent Fungal Polyketide Biosynthesis Pathway through Regulatory Cross Talk with a Cryptic Nonribosomal Peptide Synthetase Gene Cluster

Filamentous fungi produce numerous natural products that constitute a consistent source of potential drug leads, yet it seems that the majority of natural products are overlooked since most biosynthesis gene clusters are silent under standard cultivation conditions. Screening secondary metabolite ge...

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Autors principals: Bergmann, Sebastian, Funk, Alexander N., Scherlach, Kirstin, Schroeckh, Volker, Shelest, Ekaterina, Horn, Uwe, Hertweck, Christian, Brakhage, Axel A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Mycology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008269/
https://ncbi.nlm.nih.gov/pubmed/20952652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00683-10
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