Activation of a Silent Fungal Polyketide Biosynthesis Pathway through Regulatory Cross Talk with a Cryptic Nonribosomal Peptide Synthetase Gene Cluster

Filamentous fungi produce numerous natural products that constitute a consistent source of potential drug leads, yet it seems that the majority of natural products are overlooked since most biosynthesis gene clusters are silent under standard cultivation conditions. Screening secondary metabolite ge...

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Detalhes bibliográficos
Main Authors: Bergmann, Sebastian, Funk, Alexander N., Scherlach, Kirstin, Schroeckh, Volker, Shelest, Ekaterina, Horn, Uwe, Hertweck, Christian, Brakhage, Axel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Mycology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008269/
https://ncbi.nlm.nih.gov/pubmed/20952652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00683-10
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