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LC-MS/MS determination of etravirine in rat plasma and its application in pharmacokinetic studies

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that is active against NNRT-resistant HIV-1. A simple, sensitive, and specific LC-MS/MS method was developed and validated for the analysis of etravirine in rat plasma using itraconazole as the internal standard. The analytes wer...

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Détails bibliographiques
Auteurs principaux: Abobo, Cyril, Wu, Lei, John, Jyothy, Joseph, Mathew K., Bates, Theodore R., Liang, Dong
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008212/
https://ncbi.nlm.nih.gov/pubmed/20965798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2010.09.016
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