Physiological Basis for Inhibition of Morphine and Improgan Antinociception by CC12, a P450 Epoxygenase Inhibitor

Many analgesic drugs, including μ-opioids, cannabinoids, and the novel nonopioid analgesic improgan, produce antinociception by actions in the rostral ventromedial medulla (RVM). There they activate pain-inhibiting neurons, termed “off-cells,” defined by a nociceptive reflex-related pause in activit...

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Autores principales: Heinricher, Mary M., Maire, Jennifer J., Lee, Delaina, Nalwalk, Julia W., Hough, Lindsay B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007650/
https://ncbi.nlm.nih.gov/pubmed/20926616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00681.2010
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