Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

With trauma, sepsis, cancer, or uremia, animals or patients experience accelerated degradation of muscle protein in the ATP-ubiquitin-proteasome (Ub-P’some) system. The initial step in myofibrillar proteolysis is unknown because this proteolytic system does not break down actomyosin complexes or myo...

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Bibliografiske detaljer
Main Authors: Du, Jie, Wang, Xiaonan, Miereles, Christiane, Bailey, James L., Debigare, Richard, Zheng, Bin, Price, S. Russ, Mitch, William E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC300763/
https://ncbi.nlm.nih.gov/pubmed/14702115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200418330
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