Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

Children with Down's syndrome (DS) have 20–50-fold higher incidence of all leukaemias (lymphoid and myeloid), for reasons not understood. As incidence of many solid tumours is much lower in DS, we speculated that disturbed early haematopoietic differentiation could be the cause of increased leu...

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Autori principali: De Vita, S, Canzonetta, C, Mulligan, C, Delom, F, Groet, J, Baldo, C, Vanes, L, Dagna-Bricarelli, F, Hoischen, A, Veltman, J, Fisher, E M C, Tybulewicz, V L J, Nizetic, D
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007620/
https://ncbi.nlm.nih.gov/pubmed/20697343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.351
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