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Hypoxia induces tri-methylated H3 lysine 4 by inhibition of JARID1A demethylase

Histone H3 Lysine 4 (H3K4) tri-methylation (H3K4me3) at the promoter region of genes has been linked to transcriptional activation. In the present study, we found that hypoxia (1 % oxygen) increased H3K4me3 in both normal human bronchial epithelial Beas-2B cells and human lung carcinoma A549 cells....

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Detalhes bibliográficos
Main Authors: Zhou, Xue, Sun, Hong, Chen, Haobin, Zavadil, Jiri, Kluz, Thomas, Arita, Adriana, Costa, Max
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007597/
https://ncbi.nlm.nih.gov/pubmed/20406991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2942
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