HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer

Herceptin (trastuzumab) is used in patients with breast cancer who have HER2 (ErbB2)–positive tumours. However, its mechanisms of action and how acquired resistance to Herceptin occurs are still poorly understood. It was previously thought that the anti-HER2 monoclonal antibody Herceptin inhibits HE...

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Hlavní autoři: Gijsen, Merel, King, Peter, Perera, Tim, Parker, Peter J., Harris, Adrian L., Larijani, Banafshé, Kong, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006345/
https://ncbi.nlm.nih.gov/pubmed/21203579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000563
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