Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates

The CagA protein of Helicobacter pylori interacts with numerous cellular factors, and is associated with increased virulence and risk of gastric carcinoma. We present here the co-crystal structure of a subdomain of CagA with the human kinase PAR1b/MARK2, revealing that a CagA peptide mimics substrat...

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Main Authors: Neišić, Dragana, Miller, Marshall C., Quinkert, Zachary T., Stein, Markus, Chait, Brian T., Stebbins, C. Erec
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006182/
https://ncbi.nlm.nih.gov/pubmed/19966800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1705
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