A Novel Cell Permeant Peptide Inhibitor of MAPKAP Kinase II Inhibits Intimal Hyperplasia in a Human Saphenous Vein Organ Culture Model

OBJECTIVE: The present study was aimed at developing a new cell-permeant peptide inhibitor (MK2i) of the kinase that phosphorylates and activates HSP27 (MAPKAP kinase II), and evaluating the ability of this peptide to inhibit HSP27 phosphorylation and intimal thickening. DESIGN OF STUDY: The ability...

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מידע ביבליוגרפי
Main Authors: Lopes, Luciana B., Brophy, Colleen M., Flynn, Charles R., Yi, Zhengping, Bowen, Benjamin P., Smoke, Christopher, Seal, Brandon, Panitch, Alyssa, Komalavilas, Padmini
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005888/
https://ncbi.nlm.nih.gov/pubmed/20864298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jvs.2010.06.168
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