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Autoinhibition of GEF activity in intersectin 1 is mediated by the short SH3-DH domain linker
Intersectin 1L (ITSN1L) acts as a specific guanine nucleotide exchange factor (GEF) for the small guanine nucleotide binding protein Cdc42 via its C-terminal DH domain. Interestingly, constructs of ITSN1L that comprise additional domains, for instance the five SH3 domains amino-terminal of the DH do...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005787/ https://ncbi.nlm.nih.gov/pubmed/20842712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.500 |
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