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Comparison of the kinetics and extent of muscarinic M(1)-M(5)receptor internalization, recycling and downregulation in Chinese Hamster Ovary cells

We characterized agonist-induced internalization, recycling and downregulation of each muscarinic receptor subtype (M(1) – M(5)) stably expressed in Chinese hamster ovary (CHO) cells. The radioligands [(3)H]QNB and [(3)H]NMS were used to measure the total and plasma membrane populations of muscarini...

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Detalhes bibliográficos
Main Authors: Thangaraju, Arunkumar, Sawyer, Gregory W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005630/
https://ncbi.nlm.nih.gov/pubmed/21044619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.10.054
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