The defect in CEACAM family member expression in Crohn’s disease IECs is regulated by the transcription factor SOX9

BACKGROUND: CEACAM1, CEACAM5 and CEACAM6 represent three of the CEACAM subfamily members expressed on intestinal epithelial cells (IECs). Deficiency in their expression, as seen in inflammatory bowel disease (IBD), results in the lack of activation of CD8+ regulatory T cells in the mucosa. Since CEA...

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Bibliographic Details
Main Authors: Roda, Giulia, Dahan, Stephanie, Mezzanotte, Laura, Caponi, Alessandra, Roth-Walter, Franziska, Pinn, David, Mayer, Lloyd
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005567/
https://ncbi.nlm.nih.gov/pubmed/19637360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21023
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