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The defect in CEACAM family member expression in Crohn’s disease IECs is regulated by the transcription factor SOX9
BACKGROUND: CEACAM1, CEACAM5 and CEACAM6 represent three of the CEACAM subfamily members expressed on intestinal epithelial cells (IECs). Deficiency in their expression, as seen in inflammatory bowel disease (IBD), results in the lack of activation of CD8+ regulatory T cells in the mucosa. Since CEA...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005567/ https://ncbi.nlm.nih.gov/pubmed/19637360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21023 |
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