Physiological loading of joints prevents cartilage degradation through CITED2

Both overuse and disuse of joints up-regulate matrix metalloproteinases (MMPs) in articular cartilage and cause tissue degradation; however, moderate (physiological) loading maintains cartilage integrity. Here, we test whether CBP/p300-interacting transactivator with ED-rich tail 2 (CITED2), a mecha...

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Detalhes bibliográficos
Main Authors: Leong, Daniel J., Li, Yong H., Gu, Xiang I., Sun, Li, Zhou, Zuping, Nasser, Philip, Laudier, Damien M., Iqbal, Jameel, Majeska, Robert J., Schaffler, Mitchell B., Goldring, Mary B., Cardoso, Luis, Zaidi, Mone, Sun, Hui B.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005439/
https://ncbi.nlm.nih.gov/pubmed/20826544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-164277
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