Physiological loading of joints prevents cartilage degradation through CITED2

Both overuse and disuse of joints up-regulate matrix metalloproteinases (MMPs) in articular cartilage and cause tissue degradation; however, moderate (physiological) loading maintains cartilage integrity. Here, we test whether CBP/p300-interacting transactivator with ED-rich tail 2 (CITED2), a mecha...

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Bibliographic Details
Main Authors:	Leong, Daniel J., Li, Yong H., Gu, Xiang I., Sun, Li, Zhou, Zuping, Nasser, Philip, Laudier, Damien M., Iqbal, Jameel, Majeska, Robert J., Schaffler, Mitchell B., Goldring, Mary B., Cardoso, Luis, Zaidi, Mone, Sun, Hui B.
Format:	Artigo
Language:	Inglês
Published:	Federation of American Societies for Experimental Biology 2011
Subjects:	Research Communications
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3005439/ https://ncbi.nlm.nih.gov/pubmed/20826544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-164277
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Physiological loading of joints prevents cartilage degradation through CITED2

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