Chronic AMD3100 Antagonism of SDF-1α-CXCR4 Exacerbates Cardiac Dysfunction and Remodeling after Myocardial Infarction

The role of the SDF-1α-CXCR4 axis in response to myocardial infarction is unknown. We addressed it using the CXCR4 antagonist, AMD3100, to block SDF-1α interaction with CXCR4 after chronic coronary artery ligation. Chronic AMD3100 treatment decreased ejection fraction and fractional shortening in mi...

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Detalhes bibliográficos
Main Authors: Dai, Shujing, Yuan, Fangping, Mu, Jingyao, Li, Chengxin, Chen, Ning, Guo, Shangzhi, Kingery, Justin, Prabhu, Sumanth D., Bolli, Roberto, Rokosh, Gregg
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005152/
https://ncbi.nlm.nih.gov/pubmed/20655922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.07.010
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