Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine

PURPOSE: A novel nanomedicine, CYT-6091, constructed by simultaneously binding recombinant human tumor necrosis factor alpha (rhTNF) and thiolyated polyethylene glycol to the surface of 27 nm colloidal gold particles, was tested in a phase I dose escalation clinical trial in advanced-stage cancer pa...

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Autores principales: Libutti, Steven K., Paciotti, Giulio F., Byrnes, Adriana A., Alexander, H. Richard, Gannon, William E., Walker, Melissa, Seidel, Geoffrey D., Yuldasheva, Nargiza, Tamarkin, Lawrence
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004980/
https://ncbi.nlm.nih.gov/pubmed/20876255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0978
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