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Opioid chronopharmacology: influence of timing of infusion on fentanyl’s analgesic efficacy in healthy human volunteers

Chronopharmacology studies the effect of the timing of drug administration on drug effect. Here, we measured the influence of 4 timing moments on fentanyl-induced antinociception in healthy volunteers. Eight subjects received 2.1 μg/kg intravenous fentanyl at 2 pm and 2 am, with at least 2 weeks bet...

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Bibliografiske detaljer
Main Authors: Boom, Merel, Grefkens, Joost, van Dorp, Eveline, Olofsen, Erik, Lourenssen, Gertjan, Aarts, Leon, Dahan, Albert, Sarton, Elise
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004635/
https://ncbi.nlm.nih.gov/pubmed/21197322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S13616
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