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The Inhibitory Action of P56 on Select Functions of E1 Mediates Interferon's Effect on Human Papillomavirus DNA Replication

The interferon (IFN)-induced protein P56 inhibits human papillomavirus (HPV) DNA replication by binding to HPV E1, which has several distinct functions in initiating viral DNA replication. Here, we determined that P56 inhibited HPV type 18 (HPV18) E1's DNA helicase activity, E2 binding, and HPV...

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Bibliografiske detaljer
Main Authors: Saikia, Paramananda, Fensterl, Volker, Sen, Ganes C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004335/
https://ncbi.nlm.nih.gov/pubmed/20926571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01194-10
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