Codon Optimization of Human Parvovirus B19 Capsid Genes Greatly Increases Their Expression in Nonpermissive Cells

Parvovirus B19 (B19V) is pathogenic for humans and has an extreme tropism for human erythroid progenitors. We report cell type-specific expression of the B19V capsid genes (VP1 and VP2) and greatly increased B19V capsid protein production in nonpermissive cells by codon optimization. Codon usage lim...

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Detalhes bibliográficos
Main Authors: Zhi, Ning, Wan, Zhihong, Liu, Xiaohong, Wong, Susan, Kim, Dong Joo, Young, Neal S., Kajigaya, Sachiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004325/
https://ncbi.nlm.nih.gov/pubmed/20943969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00912-10
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