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A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-Native Small Molecules

Staphylococcus aureus (S. aureus) is a Gram-positive bacterial pathogen that has emerged as a major public health threat. Here we report that the cell wall of S. aureus can be covalently re-engineered to contain non-native small molecules. This process makes use of endogenous levels of the bacterial...

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Bibliografiske detaljer
Main Authors: Nelson, James W., Chamessian, Alexander G., McEnaney, Patrick J., Murelli, Ryan P., Kazmiercak, Barbara I., Spiegel, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003768/
https://ncbi.nlm.nih.gov/pubmed/20923200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100195d
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