Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis in Staphylococcus aureus

Both Gram-positive and Gram-negative bacteria contain bactoprenol-dependent biosynthetic pathways expressing non-essential cell surface polysaccharides that function as virulence factors. Although these polymers are not required for bacterial viability in vitro, genes in many of the biosynthetic pat...

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Main Authors: Swoboda, Jonathan G., Meredith, Timothy C., Campbell, Jennifer, Brown, Stephanie, Suzuki, Takashi, Bollenbach, Tobias, Malhowski, Amy J., Kishony, Roy, Gilmore, Michael S., Walker, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787957/
https://ncbi.nlm.nih.gov/pubmed/19689117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900151k
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