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Heterodimerization of BAK and MCL-1 Activated by Detergent Micelles

BAK is a key protein mediating mitochondrial outer membrane permeabilization; however, its behavior in the membrane is poorly understood. Here, we characterize the conformational changes in BAK and MCL-1 using detergents to mimic the membrane environment and study their interaction by in vitro pulld...

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Detalles Bibliográficos
Main Authors: Liu, Qian, Gehring, Kalle
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003418/
https://ncbi.nlm.nih.gov/pubmed/21036904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144857
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