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Perturbed Heme Binding Is Responsible for the Blistering Phenotype Associated with Mutations in the Caenorhabditis elegans Dual Oxidase 1 (DUOX1) Peroxidase Domain
Dual oxidase (DUOX) enzymes support a wide variety of essential reactions, from cellular signaling to thyroid hormone biosynthesis. In Caenorhabditis elegans, the DUOX system (CeDUOX1/2) plays a crucial role in innate immunity and in stabilizing the cuticle by forming tyrosine cross-links. The curre...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003398/ https://ncbi.nlm.nih.gov/pubmed/20947510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170902 |
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