Novel Anti-carbohydrate Antibodies Reveal the Cooperative Function of Sulfated N- and O-Glycans in Lymphocyte Homing

Cell surface glycans play pivotal roles in immune cell trafficking and immunity. Here we present an efficient method for generating anti-carbohydrate monoclonal antibodies (mAbs) using gene-targeted mice and describe critical glycans in lymphocyte homing. We immunized sulfotransferase GlcNAc6ST-1 an...

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Bibliografiske detaljer
Main Authors: Hirakawa, Jotaro, Tsuboi, Koichiro, Sato, Kaori, Kobayashi, Motohiro, Watanabe, Sota, Takakura, Atsushi, Imai, Yasuyuki, Ito, Yuki, Fukuda, Minoru, Kawashima, Hiroto
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003387/
https://ncbi.nlm.nih.gov/pubmed/20929857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167296
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