DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target

Constitutive activation of the NF-κB transcription factor plays a key role in chronic colonic inflammation and colon tumorigenesis. However, the mechanisms by which the tightly regulated NF-κB pathway becomes constitutively activated during colonic pathogenesis remain obscure. Here, we report that P...

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Hlavní autoři: Qu, Zhaoxia, Yan, Pengrong, Fu, Jing, Jiang, Jing, Grusby, Michael J, Smithgall, Thomas E, Xiao, Gutian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003295/
https://ncbi.nlm.nih.gov/pubmed/20145149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3263
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