Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

Thrombolysis with recombinant tissue plasminogen activator (rtPA) improves outcome in animal models of stroke and in clinical trial, but is associated with increased intracranial hemorrhage. Here, we explore the impact of biologic and experimental design factors on efficacy and bleeding. We conducte...

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Detaylı Bibliyografya
Asıl Yazarlar: Sena, Emily S, Briscoe, Catherine L, Howells, David W, Donnan, Geoffrey A, Sandercock, Peter A G, Macleod, Malcolm R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2010
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002882/
https://ncbi.nlm.nih.gov/pubmed/20648038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.116
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