Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

Thrombolysis with recombinant tissue plasminogen activator (rtPA) improves outcome in animal models of stroke and in clinical trial, but is associated with increased intracranial hemorrhage. Here, we explore the impact of biologic and experimental design factors on efficacy and bleeding. We conducte...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Sena, Emily S, Briscoe, Catherine L, Howells, David W, Donnan, Geoffrey A, Sandercock, Peter A G, Macleod, Malcolm R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2010
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002882/
https://ncbi.nlm.nih.gov/pubmed/20648038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.116
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