Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis

Thrombolysis with recombinant tissue plasminogen activator (rtPA) improves outcome in animal models of stroke and in clinical trial, but is associated with increased intracranial hemorrhage. Here, we explore the impact of biologic and experimental design factors on efficacy and bleeding. We conducte...

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Main Authors: Sena, Emily S, Briscoe, Catherine L, Howells, David W, Donnan, Geoffrey A, Sandercock, Peter A G, Macleod, Malcolm R
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002882/
https://ncbi.nlm.nih.gov/pubmed/20648038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.116
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