The Protein Interaction Network of the Human Transcription Machinery Reveals a Role for the Conserved GTPase RPAP4/GPN1 and Microtubule Assembly in Nuclear Import and Biogenesis of RNA Polymerase II

RNA polymerase II (RNAPII), the 12-subunit enzyme that synthesizes all mRNAs and several non-coding RNAs in eukaryotes, plays a central role in cell function. Although multiple proteins are known to regulate the activity of RNAPII during transcription, little is known about the machinery that contro...

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Bibliographische Detailangaben
Hauptverfasser: Forget, Diane, Lacombe, Andrée-Anne, Cloutier, Philippe, Al-Khoury, Racha, Bouchard, Annie, Lavallée-Adam, Mathieu, Faubert, Denis, Jeronimo, Célia, Blanchette, Mathieu, Coulombe, Benoit
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002788/
https://ncbi.nlm.nih.gov/pubmed/20855544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.003616
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