Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-κB-dependent transcription of TNF-α and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA

BACKGROUND: Tetra-O-methyl nordihydroguaiaretic acid, also known as terameprocol (TMP), is a naturally occurring phenolic compound found in the resin of the creosote bush. We have shown previously that TMP will suppress production of certain inflammatory cytokines, chemokines and lipids from macroph...

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Main Authors: Oyegunwa, Akinbolade O, Sikes, Michael L, Wilson, Jason R, Scholle, Frank, Laster, Scott M
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002343/
https://ncbi.nlm.nih.gov/pubmed/21138578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-7-59
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