Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome

BACKGROUND: Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication. METHODOLOGY AND PRINCIPAL FINDINGS...

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Hlavní autoři: Coenen, Marieke J. H., Enevold, Christian, Barrera, Pilar, Schijvenaars, Mascha M. V. A. P., Toonen, Erik J. M., Scheffer, Hans, Padyukov, Leonid, Kastbom, Alf, Klareskog, Lars, Barton, Anne, Kievit, Wietske, Rood, Maarten J., Jansen, Tim L., Swinkels, Dorine, van Riel, Piet L. C. M., Franke, Barbara, Bendtzen, Klaus, Radstake, Timothy R. D. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002281/
https://ncbi.nlm.nih.gov/pubmed/21179534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014326
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