Genetic Variants in Toll-Like Receptors Are Not Associated with Rheumatoid Arthritis Susceptibility or Anti-Tumour Necrosis Factor Treatment Outcome

BACKGROUND: Several studies point to a role of Toll-like receptors (TLRs) in the development of rheumatoid arthritis (RA). We investigated if genetic variants in TLR genes are associated with RA and response to tumour necrosis factor blocking (anti-TNF) medication. METHODOLOGY AND PRINCIPAL FINDINGS...

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Main Authors: Coenen, Marieke J. H., Enevold, Christian, Barrera, Pilar, Schijvenaars, Mascha M. V. A. P., Toonen, Erik J. M., Scheffer, Hans, Padyukov, Leonid, Kastbom, Alf, Klareskog, Lars, Barton, Anne, Kievit, Wietske, Rood, Maarten J., Jansen, Tim L., Swinkels, Dorine, van Riel, Piet L. C. M., Franke, Barbara, Bendtzen, Klaus, Radstake, Timothy R. D. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002281/
https://ncbi.nlm.nih.gov/pubmed/21179534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014326
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