Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism

BACKGROUND: Tissue-specific expression of CYP450s can regulate the intracellular concentration of drugs and explain inter-subject variability in drug action. The overall objective of our study was to determine in a large cohort of samples, mRNA levels and CYP450 activity expressed in the human heart...

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Bibliographic Details
Main Authors: Michaud, Veronique, Frappier, Martin, Dumas, Marie-Christine, Turgeon, Jacques
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001885/
https://ncbi.nlm.nih.gov/pubmed/21179487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015666
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