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Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism
BACKGROUND: Tissue-specific expression of CYP450s can regulate the intracellular concentration of drugs and explain inter-subject variability in drug action. The overall objective of our study was to determine in a large cohort of samples, mRNA levels and CYP450 activity expressed in the human heart...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001885/ https://ncbi.nlm.nih.gov/pubmed/21179487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015666 |
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