Enumeration of Functional T-Cell Subsets by Fluorescence-Immunospot Defines Signatures of Pathogen Burden in Tuberculosis

BACKGROUND: IFN-γ and IL-2 cytokine-profiles define three functional T-cell subsets which may correlate with pathogen load in chronic intracellular infections. We therefore investigated the feasibility of the immunospot platform to rapidly enumerate T-cell subsets by single-cell IFN-γ/IL-2 cytokine-...

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Hauptverfasser: Casey, Rosalyn, Blumenkrantz, Deena, Millington, Kerry, Montamat-Sicotte, Damien, Kon, Onn Min, Wickremasinghe, Melissa, Bremang, Samuel, Magtoto, Murphy, Sridhar, Saranya, Connell, David, Lalvani, Ajit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001879/
https://ncbi.nlm.nih.gov/pubmed/21179481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015619
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