Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A/C Gene Mutation

BACKGROUND: Lamins A and C, encoded by the LMNA gene, are filamentous proteins that form the core scaffold of the nuclear lamina. Dominant LMNA gene mutations cause multiple human diseases including cardiac and skeletal myopathies. The nuclear lamina is thought to regulate gene expression by its dir...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mewborn, Stephanie K., Puckelwartz, Megan J., Abuisneineh, Fida, Fahrenbach, John P., Zhang, Yuan, MacLeod, Heather, Dellefave, Lisa, Pytel, Peter, Selig, Sara, Labno, Christine M., Reddy, Karen, Singh, Harinder, McNally, Elizabeth
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2010
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001866/
https://ncbi.nlm.nih.gov/pubmed/21179469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014342
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