Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

BACKGROUND: Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel development and maturation. This study evaluates the efficacy of the inhibition of both signaling pathways, alone and in combination, in reducing the growth of an autochthonous mouse tumor and assesses potential...

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Главные авторы: Djokovic, Dusan, Trindade, Alexandre, Gigante, Joana, Badenes, Marina, Silva, Lilliana, Liu, Ren, Li, Xiuqing, Gong, Ming, Krasnoperov, Valery, Gill, Parkash S, Duarte, Antonio
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001720/
https://ncbi.nlm.nih.gov/pubmed/21092311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-641
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