Synergic effect of Eicosapentaenoic acid and Lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells

BACKGROUND: PUFAs are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme catalyzing the conversion of HMGCoA to mevalonate, the rate limiting step in cholesterol biosynthesis. Statins represent a class of drugs that are widely used to treat hypercholesterolemia...

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Hauptverfasser: Notarnicola, Maria, Messa, Caterina, Refolo, Maria G, Tutino, Valeria, Miccolis, Angelica, Caruso, Maria G
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001710/
https://ncbi.nlm.nih.gov/pubmed/21118482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-9-135
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