Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: a randomized, crossover, double-blind study

BACKGROUND: Interferon (IFN) alpha conjugation to polyethylene glycol (PEG) results in a better pharmacokinetic profile and efficacy. The aim of this study was to compare the pharmacokinetic, pharmacodynamic and safety properties of a new, locally developed, 40-kDa PEG-IFN alpha-2b preparation with...

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Main Authors: García-García, Idrian, González-Delgado, Carlos A, Valenzuela-Silva, Carmen M, Díaz-Machado, Alina, Cruz-Díaz, Marisol, Nodarse-Cuní, Hugo, Pérez-Pérez, Orlando, Bermúdez-Badell, Cimara H, Ferrero-Bibilonia, Joel, Páez-Meireles, Rolando, Bello-Rivero, Iraldo, Castro-Odio, Fidel R, López-Saura, Pedro A
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001701/
https://ncbi.nlm.nih.gov/pubmed/21092287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2210-10-15
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