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Cisplatin and PI3Kinase Inhibition decrease Invasion and Migration of Human Ovarian Carcinoma Cells and regulate Matrix-Metalloproteinase Expression

Targeting of the PI3K (phosphoinositide3-kinase)/Akt/mTOR pathway in human ovarian cancer cells is a promising novel therapeutic strategy. We investigated the effects of cisplatin and the PI3K inhibitor LY294002 on invasion, migration and the expression of essential matrix metalloproteinases (MMPs)...

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Autors principals: Karam, Amer K., Santiskulvong, Chintda, Fekete, Mirela, Eng, Carol, Dorigo, Oliver
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001291/
https://ncbi.nlm.nih.gov/pubmed/20607860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cm.20465
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