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Cisplatin and PI3Kinase Inhibition decrease Invasion and Migration of Human Ovarian Carcinoma Cells and regulate Matrix-Metalloproteinase Expression
Targeting of the PI3K (phosphoinositide3-kinase)/Akt/mTOR pathway in human ovarian cancer cells is a promising novel therapeutic strategy. We investigated the effects of cisplatin and the PI3K inhibitor LY294002 on invasion, migration and the expression of essential matrix metalloproteinases (MMPs)...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001291/ https://ncbi.nlm.nih.gov/pubmed/20607860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cm.20465 |
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