Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase For Remodeling Bacterial RNA Polymerase

The NtrC-like AAA+ ATPases control virulence and other important bacterial activities through delivering mechanical work to σ54-RNA polymerase to activate transcription from σ54-dependent genes. We report the first crystal structure for such an ATPase, NtrC1 of Aquifex aeolicus, in which the catalyt...

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Main Authors: Chen, Baoyu, Sysoeva, Tatyana A., Chowdhury, Saikat, Guo, Liang, De Carlo, Sacha, Hanson, Jeffrey A., Yang, Haw, Nixon, B. Tracy
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001195/
https://ncbi.nlm.nih.gov/pubmed/21070941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.08.018
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