Negative regulation of CD8 expression via CD8 enhancer-mediated recruitment of the zinc finger protein MAZR

Coreceptor expression is tightly regulated during thymocyte development. Deletion of specific Cd8 enhancers leads to variegated expression of CD8αβ heterodimers in double-positive (DP) thymocytes. Here we show CD8 variegation was correlated with an epigenetic “off” state, linking Cd8 enhancer functi...

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Huvudupphovsmän: Bilic, Ivan, Koesters, Christina, Unger, Bernd, Sekimata, Masayuki, Hertweck, Arnulf, Maschek, Romana, Wilson, Christopher B., Ellmeier, Wilfried
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2006
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001192/
https://ncbi.nlm.nih.gov/pubmed/16491076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1311
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