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Negative regulation of CD8 expression via CD8 enhancer-mediated recruitment of the zinc finger protein MAZR
Coreceptor expression is tightly regulated during thymocyte development. Deletion of specific Cd8 enhancers leads to variegated expression of CD8αβ heterodimers in double-positive (DP) thymocytes. Here we show CD8 variegation was correlated with an epigenetic “off” state, linking Cd8 enhancer functi...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001192/ https://ncbi.nlm.nih.gov/pubmed/16491076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1311 |
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