Brain Endothelial Cells Produce Amyloid β from Amyloid Precursor Protein 770 and Preferentially Secrete the O-Glycosylated Form

Deposition of amyloid β (Aβ) in the brain is closely associated with Alzheimer disease (AD). Aβ is generated from amyloid precursor protein (APP) by the actions of β- and γ-secretases. In addition to Aβ deposition in the brain parenchyma, deposition of Aβ in cerebral vessel walls, termed cerebral am...

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Detalhes bibliográficos
Main Authors: Kitazume, Shinobu, Tachida, Yuriko, Kato, Masaki, Yamaguchi, Yoshiki, Honda, Takashi, Hashimoto, Yasuhiro, Wada, Yoshinao, Saito, Takashi, Iwata, Nobuhisa, Saido, Takaomi, Taniguchi, Naoyuki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000992/
https://ncbi.nlm.nih.gov/pubmed/20952385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144626
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