Heteromeric Interactions Required for Abundance and Subcellular Localization of Human CDC50 Proteins and Class 1 P(4)-ATPases

Members of the P(4) family of P-type ATPases (P(4)-ATPases) are believed to function as phospholipid flippases in complex with CDC50 proteins. Mutations in the human class 1 P(4)-ATPase gene ATP8B1 cause a severe syndrome characterized by impaired bile flow (intrahepatic cholestasis), often leading...

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Hlavní autoři: van der Velden, Lieke M., Wichers, Catharina G. K., van Breevoort, Adriana E. D., Coleman, Jonathan A., Molday, Robert S., Berger, Ruud, Klomp, Leo W. J., van de Graaf, Stan F. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000991/
https://ncbi.nlm.nih.gov/pubmed/20947505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.139006
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