Heteromeric Interactions Required for Abundance and Subcellular Localization of Human CDC50 Proteins and Class 1 P(4)-ATPases

Members of the P(4) family of P-type ATPases (P(4)-ATPases) are believed to function as phospholipid flippases in complex with CDC50 proteins. Mutations in the human class 1 P(4)-ATPase gene ATP8B1 cause a severe syndrome characterized by impaired bile flow (intrahepatic cholestasis), often leading...

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Autori principali: van der Velden, Lieke M., Wichers, Catharina G. K., van Breevoort, Adriana E. D., Coleman, Jonathan A., Molday, Robert S., Berger, Ruud, Klomp, Leo W. J., van de Graaf, Stan F. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Membrane Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000991/
https://ncbi.nlm.nih.gov/pubmed/20947505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.139006
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