High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity

The mobilization and extracellular release of nuclear high mobility group box-1 (HMGB1) by ischemic cells activates inflammatory pathways following liver ischemia/reperfusion (I/R) injury. In immune cells such as macrophages, post-translational modification by acetylation appears to be critical for...

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Main Authors: Evankovich, John, Cho, Sung W., Zhang, Ruilin, Cardinal, Jon, Dhupar, Rajeev, Zhang, Lemeng, Klune, John R., Zlotnicki, Jason, Billiar, Timothy, Tsung, Allan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000970/
https://ncbi.nlm.nih.gov/pubmed/20937823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.128348
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