Acquisition of Temozolomide Chemoresistance in Gliomas Leads to Remodeling of Mitochondrial Electron Transport Chain

Temozolomide (TMZ) is an oral alkylating agent used for the treatment of high-grade gliomas. Acquired chemoresistance is a severe limitation to this therapy with more than 90% of recurrent gliomas showing no response to a second cycle of chemotherapy. Efforts to better understand the underlying mech...

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Autori principali: Oliva, Claudia R., Nozell, Susan E., Diers, Anne, McClugage, Samuel G., Sarkaria, Jann N., Markert, James M., Darley-Usmar, Victor M., Bailey, Shannon M., Gillespie, G. Yancey, Landar, Aimee, Griguer, Corinne E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Bioenergetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000957/
https://ncbi.nlm.nih.gov/pubmed/20870728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.147504
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